Study of the immunomodulating influence of preparation alpha/beta-defensins on chemo/radiotherapy of patients with oral and oropharyngeal cancer

The state of antitumor immunity patients with oral cavity and oropharyngeal cancer during treatment (radiation chemoradiation therapy), which additionally included α/β-defensin immunotherapy, was studied. In all three study groups, where preparation α/β-defensins used, there a more pronounced dose-dependent decrease in the relative number lymphocytes blood than among those receiving cytostatic therapy mono mode. Patients group I received radiation II - III immunotherapy increased doses, VI radiation, V chemoradiation. Thus, І absolute by 0.6×109/l, 0.82×109/l, 0.93×109/l; 8.51% I, 15.52% 14.32%. A significant CD3+ T cells registered combination radiation- immunotherapy: from 1141×106/l to 682×106/l 871×106/l 309×106/l. At same time, an increase natural killers undergoing also effect, growth is 16 17% 13.4 19.5%. Among therapy, were differences NKT groups III, reducing these 86 57 62 31, respectively. have been shown adjuvant effect on – oropharynx. Simultaneously use drug associated additional immunomodulatory form restructuring subpopulation due blood.